Reposted from Life Extensionhttp://blog.lef.org/2012/03/resveratrol-can-prevent-disease.html
By Michael A. Smith, MD
We like resveratrol, especially the early research showing that it favorably expresses anti-aging genes and prevents cancer — at least in mice. But there’s so much more to what my dad calls, the “red wine” supplement. New research highlights several mechanisms of action by which resveratrol can help prevent and even treat disease.
The table below comes from a systematic review of resveratrol research.1 We added the section on synergistic nutrients that could be taken with resveratrol for added benefit. Although the investigators concluded that more human research is needed, they believe that resveratrol looks promising for preventing cancer, heart disease and even diabetes.
Resveratrol’s Mechanisms of Action
Mechanism of Action
|Reduces Oxidative Stress||All age-related diseases||Antioxidants from dark berries |
|Eases Inflammation||All age-related diseases||Omega-3 Fats |
Curcumin (turmeric spice)
Boswellia serrata extract
|Suppresses fat cell formation |
Stimulates fat cell breakdown
|Obesity, heart disease, diabetes||Mangosteen & S. Indicus |
Fucoxanthin (brown seaweed)
Conjugated linoleic acid
|Enhances cell energy production |
Protects mitochondrial decay
|Obesity, heart disease, diabetes||Ubiquinol CoQ10 |
PQQ (Pyrroloquinoline quinone)
|Promotes healthy cell growth|
Controls programmed cell death
|Cancer||Cruciferous vegetable extract |
Coriolus mushroom extract
|Inhibition of metastasis||Cancer||Curcumin|
|Controls of angiogenesis |
(blood vessel formation)
|Cancer||Green tea extract (EGCG) |
Milk thistle (silibinin)
|Prevents DNA damage||Cancer||Chlorophyllin|
|Improves toxin metabolism||Cancer||Modified citrus pectin|
|Reduce levels of glutamate||Brain and nerve disorders||Blueberry extracts |
|Promotes bone formation||Osteoporosis||Dried plum extract |
What You Need to KnowResveratrol, a natural polyphenol antioxidant, has several key mechanisms of action, each of which contributes to the reduction of disease and even premature death. Five of the leading causes of death may be prevented or mitigated by resveratrol supplementation, including heart disease, cancer, stroke, Alzheimer’s disease and diabetes. All of this put together, makes resveratrol an important part of every wellness program.
Want to dig even deeper? Check out the entire article, How Resveratrol Combats Leading Causes of Death, from the March issue of Life Extension Magazine®.
- PLoS One. 2011;6(6):e19881.