Friday, November 16, 2018

How can a gut injury lead to a brain injury?

by Keith Bell

Let's focus on serotonin imbalance related to glutamate excitotoxicity to answer this question. About 95% of the body's serotonin is produced in the gut, not the brain.  Gastrointestinal symptoms such as constipation and diarrhea are associated with serotonin imbalances in blood. In constipation, serotonin is retained in mucosal cells of the intestine leading to low levels in blood. In diarrhea, serotonin is released and inflammatory. But it's low levels of serotonin in blood which may be most associated with glutamate toxicity and brain damage. This construct is applied to SIDS, SUDEP, epilepsy and vaccine injury.
Experiments regarding serotonin levels altered by vaccination include dramatic changes in sensitivity to the lethal effects of serotonin. Some vaccines may dramatically increase serotonin, while others such as BCG (tuberculosis vaccine) appear to lower serotonin to the extent of SSRI resistance leading to depression. Thimerosal(mercury) was found to cause exocytotic release of serotonin. Sertotonin levels may rise and then fall dramatically in vaccination.

To illustrate the order of events from gut-to-brain (vaccination to gut disturbance to serotonin imbalance to glutamate excitotoxicity), we'll use Sudden Infant Death Syndrome (SIDS) as example. SIDS is the leading cause of death among infants one month to one year old. SIDS is associated with serotonin deficiency in the brainstem:
1)   A child is born with high levels of Proteobacteria, low levels of Lactobacilli and reduced or absent Bifidobacteria along with pathogenic strains of Clostridia and high gram-negative Bacteroides, an inflammatory microbial predisposition. Vitamin B12 and folate act as cofactors in synthesis of serotonin, both regulated by flora.
2)   Vaccination begins within 12 hours of birth and continues following CDC protocol of 23 vaccinations in the first year of life leading to constipation and low blood levels of serotonin. Antibiotic abuse in newborns may also be a factor, i.e., shifting flora to raise clostridia which cross-feed hydrogen and CO2 to methanogenic archaea where methane causes constipation. 
3)   It's stated boldly in many papers that serotonin doesn't cross blood-brain barrier (BBB) as if gut-derived serotonin doesn't enter the brain, yet papers show serotonin penetrates BBB. Serotonin may also cross BBB from the brain to circulating blood. Blood and brain serotonin levels are positively correlated. Alternatively, an infant with acute tryptophan depletion leads to serotonin deficiency in the brain where tryptophan level is dependent on gut microbiota and enhances immune response. Bifidobacteria are known to elevate tryptophan, precursor of serotonin, while reducing serotonin metabolites in the brain. Tryptophan depletion leading to low serotonin is also the result of hypoglycemia caused by vaccination. Blood sugar is regulated by flora where insulin removes competing amino acids allowing tryptophan into the brain.
4)   CO2 chemosensors in the brainstem activate the serotonergic system. Reduced brain serotonin affects CO2 chemosensitivity. Microbial overgrowth may also affect CO2 levels in blood as microbes utilize CO2 to manufacture metabolites such as acetate. Intracellular microbes may affect CO2 production in the Krebs cycle. Note: CO2 inhalation is a technique used to halt seizure.
5)   Serotonin, or lack of serotonin, then activates thalamocortical networks associated with glutamate receptors.  Cytokines are induced by LPS (gram-negative bacterial toxins) and modulate serotonergic transmission in the brain.
6)   In SIDS, the face-down prone position means a child inhales CO2, activating the serotonergic system leading to glutamate excitotoxicity, dysregulating cardiac vagal neurons and parasympathetic activity to the heart.
Alternating constipation and diarrhea is a way of life for many. Serotonin levels may swing like pendulum. Blood levels of serotonin are high in diarrhea leading to Serotonin Syndrome. High blood levels of serotonin are known in autism where many people suffering are still in diapers as adults. Perhaps overgrown Proteobacteria are the culprit as they may be most responsible for production of tryptophan, precursor of serotonin. Constipation is also a widely known side effect of antipsychotic drugs, not yet commonly viewed as root cause of mental illness
High serotonin in blood of autistic children may be a matter of hydrogen sulfide (raising serotonin in the brain) produced by the Proteobacteria known overgrown in autism, Desulfovibrio. Seizures may be caused by both high and low serotonin, a balancing act. Scientists also report serotonin levels in autism as high in blood, but low in brain. The point is levels may be in flux based on activity in the gut and serotonin, or lack of it, activates glutamate excitotoxicity.
Dietary glutamate is thought protective and doesn't cross BBB, enhancing digestion and absorption of nutrients in the small intestine packed with glutamate receptors.  But gut dysbiosis is known to increase BBB permeability via LPS where a more porous BBB may allow circulatory glutamate into the brain. Recent research found maternalmicrobes regulate fetal BBB permeability as well as throughout life without consideration of imbalanced fetal intestinal flora causing leaky brain. Clostridial toxins induce excessive glutamate release in the hippocampus leading to seizure and neuronal damage
Recent study found high levels of glutamate in autistic subjects and excitotoxicity associated with neuroinflammation. Glutamate is a product of intestinal flora, substrate for production of butyrate and acetate. Bifidobacteria and Lactobacillus convert glutamate to calming GABA and CO2 using the enzyme glutamate decarboxylase. 


How does glutamate toxicity damage the brain?

Dr. Russell Blaylock provides an excellent overview of immunoexcitotoxicity in this video presentation.  Neurodegeneration is a matter of mitochondrial damage by intracellular calcium. Factoring intracellular microbes is not yet part of science. Cells may release endogenous glutamate based on microbial enzymatic (transaminases such as ALT) interference with the Krebs cycle. Deficiency of microbial enzymes such as glutamate dehydrogenase may also lead to mitochondrial damage as glutamate cannot be deaminated to remove excess nitrogen, so ammonia builds.  Lactobacillus paracasei is a common lactobacillus used in yogurt and cheese manufacturing and found in breast milk, prized for glutamate dehydrogenase activity, reducing ammonia overload in such scenario. Bifidobacteria are also known to reduce ammonia levels. 
Dr. Blaylock mentions formation of nitric oxide as part of immunoexcitotoxicity. Gut microbes produce nitric oxide. Nitric oxide inhibits glutamine synthetase which would otherwise clear glutamate.
Studies of excitotoxicity as cause of autism include cannabinoids as mechanism of success in calming the brain. The role of glutamate receptors in autism and the serotonin hypothesis, including use of SSRIs during pregnancy leading to increased risk of autism, awaits further study. Recent evidence reveals disturbed, excitatory glutamate metabolism in autism. 


Why are boys 5x more likely to become autistic than girls?

We'll discuss two factors: serotonin and estrogen.  Boys have naturally higher levels of tryptophan in blood, precursor to serotonin. This translates to 52% higher levels of serotonin synthesis in the male brain. Approximately 60% of SIDS victims are male despite or because of higher levels of brain serotonin. Are male infants more prone to hypoglycemia leading to tryptophan depletion due to gender differences in flora?
Differences in microbiota between male and female intestines control tryptophan metabolism affecting serotonin levels, influencing neurotransmission of the gut-brain. Papers also reveal significantly lower levels of GABA in men than women. Females adapt better than males because of differences in the GABAergic and glutamatergic systems. 
Estrogen receptors in the female brain are anti-inflammatory. A recent dietary studyillustrates how estrogen receptors of the female brain are protective in high fat diet.  What is generally not yet factored are microbial fatty acids of gut origin and how they affect the brain. It's not a simple matter of diet as we aren't the only ones consuming what's placed in our mouths.


Uric acid

Retention of uric acid in cells affecting levels in blood serum is somewhat similar to retention of serotonin and has been subject of debate for over acentury in fields of epilepsy and migraine, largely forgotten. In 1899, migraine was called a "uric acid headache."  Today, migraine treatment options includeprobiotic therapy.
In epilepsy, uric acid is retained in cells leading to low levels in serum until seizure when it is released in high levels. At optimal levels, uric acid is a natural antioxidant found protective. Elevated levels are associated with risk of stroke. These cerebral microbleeds are also the subject of vaccine brain injury as described by Dr. Andrew Moulden. Uric acid is studied as damage-associated molecular pattern (DAMP) associated with severe adverse events after vaccination. Interestingly, lactic acid bacteria (LAB) lower serum uric acid. High levels of uric acid are associated with significantly low levels of serotonin
In closing, the current one-size-fits-all approach to vaccination does not factor individual immune systems regulated by gut microbiota. In order to assess potential risk of vaccine injury, meconium and stool testing pre-vaccination to identify microbial balance is justified.
And if vaccine scientists are fortunate, new probiotic adjuvants in development will not only improve vaccine response, but also reduce risk of injury.  Unfortunately, vaccine scientists are concerned only with improving vaccine effectiveness, not safety. Most importantly, the public should become aware of how gut flora dictate immune response in order to improve general health and immunity. This is the major difference between health, injury and survival with and without vaccination.

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Sunday, November 11, 2018

60 Lab Studies Now Confirm Cancer Link to Certain Vaccine

Reposted from Health Nut News

By Dr. Mercola, board-certified physician and surgeon

Dr. Maurice Hilleman made astounding revelations in an interview that was cut from The Health Century — the admission that Merck drug company vaccines had been injecting dangerous viruses into people worldwide.
Bear in mind that Dr. Hilleman was the developer of Merck’s vaccine program. He developed over three dozen vaccines, more than any other scientist in history. He was a member of the U.S. National Academy of Science, the Institute of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society. He received a special lifetime achievement award from the World Health Organization. Hilleman was one of the early vaccine pioneers to warn about the possibility that simian viruses might contaminate vaccines.
Dr. Mercola’s Comments:
The video above has circulated for awhile, and some of you may already have seen it. But I think it’s important to revisit and remember history when it comes to vaccines, especially in light of current developments.
For starters, the HPV vaccine Gardasil, which is being vigorously pushed on unsuspecting young girls and women to theoretically guard against cervical cancer still has never been proven to actually prevent cancer. On the contrary, evidence suggests that under certain circumstances the vaccine increases your risk of precancerous lesions by nearly 45 percent, and an ever increasing number of girls are being seriously injured by this unnecessary vaccine.
As of December 13, 2010, 20,915 adverse reactions had been reported in the United States alone, including 89 deaths, 297 miscarriages or stillbirths, and 370 reports of abnormal pap smears post vaccination.
All of this from a vaccine that has only been on the market for four years!
Making matters worse, as of 2009 the US FDA approved Gardasil for use on young boys as well, and the first male death has also been reported. In September of last year, a young boy died just eight days after being vaccinated with Gardasil.
So what’s going on here?
Is it possible that vaccines sold by drugmakers like Merck are causing lethal disease? Judging by history, the answer may be yes.

Contaminated Polio Vaccine Responsible for Human Cancer Cases

In 2002, the journal Lancet published compelling evidence that contaminated polio vaccine was responsible for up to half of the 55,000 non-Hodgkin’s lymphoma cases that were occurring each year.
What was it contaminated with?
SV40, a cancer-causing monkey virus. The puzzle began in 1994, when Dr. Michele Carbone, a Loyola University researcher, found the virus SV40, which had never before been detected in humans, in half of the human lung tumors he was studying. Since then, 60 different lab studies have confirmed the results, and SV40 has been found in a variety of human cancers, including lung-, brain-, bone-, and lymphatic cancer.
At first no one could fathom how the virus had been transmitted into the human population.
But in the censored interview with Dr. Maurice Hilleman above, Hilleman admits Merck’s responsibility in unleashing this virus via their polio vaccine, as well as the likelihood that there was an importing and spreading the AIDS virus in the same manner.

Just Who is Dr. Maurice Hilleman?

Now, for those of you who may think Dr. Hilleman was just another crackpot (he passed away in 2005), think again. He was, and still is, the leading vaccine pioneer in the history of vaccines. He developed more than three dozen vaccines—more than any other scientist in history—and was the developer of Merck’s vaccine program.
He was a member of the U.S. National Academy of Science, the Institute of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society, and received a special lifetime achievement award from the World Health Organization.
When he was chief of the Department of Respiratory Diseases with what’s now the Walter Reed Army Institute of Research, he discovered the genetic changes that occur when the influenza virus mutates, known as shift and drift. He was also one of the early vaccine pioneers to warn about the possibility that simian viruses might contaminate vaccines.So Dr. Hilleman knew what he was talking about. And in his own words, “vaccines have to be considered the bargain basement technology for the 20th Century.”

Vaccines Can Cause the Very Disease They’re Meant to Prevent, and Worse

For years, researchers suggested that millions of vials of polio vaccine, contaminated with SV40, infected individuals between 1953 and 1963 and caused human tumors, and by 1999, molecular evidence of SV40 infections were showing up in children born after 1982. Some experts now suggest the virus may have remained in the polio vaccine until as late as 1999.
Still, the FDA and health authorities turned a blind eye.
In addition, just like Gardasil may well increase your risk of cervical cancer rather than reduce it, the live polio vaccine has also been found to cause polio. And, in rare instances the virus in the vaccine has even been known to mutate into a much deadlier version.  As reported by MSN News in 2009, genetic analysis has proven such mutated viruses have caused at least seven separate outbreaks in Nigeria.
According to the CDC the last case of wild polio in the US—meaning polio caused naturally and not due to the live polio vaccine—occurred in 1979. From 1980 through 1999, there were NO wild polio cases in the US. Instead we had 144 cases of vaccine-associated paralytic polio (VAPP) caused by live oral polio vaccine.
Polio outbreaks in Haiti and the Dominican Republic in 2002 were also traced back to a strain of oral polio vaccine (OPV) that mutated back to virulence.
According to a report by Neil Z. Miller of the Global Vaccine Institute, the live polio virus from the vaccine can remain in your throat for one to two weeks and in your feces for up to two months. So not only is the vaccine recipient at risk, but he or she can potentially spread the disease to others.
In 1999, the Advisory Committee on Immunization Practices (ACIP) recommended that the United States replace the live-virus vaccine with an inactivated “killed” virus vaccine, which is what remains in use today. However, the inactivated polio virus vaccine has not been without its share of serious side effects either.

Rotavirus Vaccine Contaminated with Pig Virus

Last year, the US FDA suspended the rotavirus vaccine Rotarix after an independent lab discovered it was contaminated with “a substantial amount” of DNA from the porcine circovirus. In pigs, this virus causes poor growth, weight loss, weakness, enlarged lymph nodes, skin rashes, difficulty breathing, jaundice, stomach ulcers, and sudden death.
As expected, both the FDA and GlaxoSmithKline spokespeople stated that the contaminated Rotarix vaccine carried no known human health risks. However, this is easy to say since there are no studies to confirm or deny a link between these viruses and human disease.
In the case of the polio vaccine, the link between the SV40 virus and human cancer wasn’t discovered until 40 years later!  It is actually surprisingly common for vaccines to contain various animal matter, including foreign animal tissues containing genetic material (DNA/RNA).
Once the Rotarix contamination was discovered, new technology was used to test eight infectious attenuated viral vaccines, and in addition to Rotarix, two others contained “unexpected viral sequences”:
  1. A measles vaccine was found to contain low levels of the retrovirus avian leukosis (AVL) virus—a virus known to cause cancer in chickens. This despite the fact that vaccine manufacturers have been required to use eggs from leucosis-free stocks for over 40 years.
  2. Rotateq, Merck’s rotavirus vaccine, was found to contain a virus similar to simian (monkey) retrovirus—the SV40 virus previously linked to human cancer.
Are you willing to bet that they a) know what they’re talking about, and b) are telling the whole truth and nothing but the truth about the potential health dangers of all these vaccines?

HPV Vaccine Now Routine for Boys as Well…

So far, very few parents have voluntarily lined up their sons for the HPV vaccine, but that may soon change. As reported by Paging Dr. Gupta, the American Academy of Pediatrics’ 2011 schedule of recommended routine vaccines for children and teens now includes the HPV vaccine for boys aged 9-18 as well.
Folks, this is a disaster in the making. I shudder to think about the statistics we’ll see in a few years if parents fall for this nonsense.
I urge you to consider the risks already revealed in the four short years since Gardasil came on the market. Already, there are close to 21,000 reported incidents of adverse effects and death, despite the fact that only two out of every 10 women in the approved age group have gotten the vaccine so far.
Add to this the fact that an estimated 90 to 99 percent of all adverse effects are never reported, and the abnormally large risks of the HPV vaccine compared to other vaccines should give most people reason to pause.
Although the FDA ultimately dismisses all side effects, including deaths, as being within the norm, even they have stated that:
“In VAERS, a higher proportion of Gardasil reports were of syncope [fainting] and VTEs [venous thromboembolic events] compared with other vaccines.
And according to the National Vaccine Information Center, the incidents of miscarriage and still birth events from Gardasil supersede the same event from all other vaccinations.
According to a recent Sane Vax press release on PR Log:
“There is no doubt the vaccine’s safety and efficacy has not been thoroughly investigated. And independent investigation on the safety and efficacy of the HPV vaccines, Gardasil and Cervarix must be conducted before there are more injuries and deaths.”
What’s most frustrating about this is that not a single one of these 21,000 children and young women needed to be harmed or die.
There are still outstanding questions about whether HPV is or is not the direct cause of cervical cancer. The FDA knows there are many other co-factors involved with the development of cervical cancer, and as of 2003 acknowledged that “most infections (by HPV) are short-lived and not associated with cervical cancer.” The same news release also states that “with proper screening, cervical cancer is avoidable, and if caught early, curable.”
In essence, three years before the HPV vaccine came upon the scene, they knew that what was needed—if anything—was simply improved screening methods, such as regular pap smear testing for girls and women that are far less risky than getting an HPV shot.
Interestingly, and disturbingly, routine pap smears have DECLINED, coinciding neatly with the release of the HPV vaccine. Between 2007 and 2010, cervical cancer screening rates declined by nearly 7 percent, the New York Times reported in December of last year.
When you consider that the HPV vaccine increases your risk of cancer if you’re already infected with certain types of HPV, this is a double-whammy of bad news since rarely, if ever, are girls and women given HPV pap screening before they get an HPV shot.
It’s all madness! Not only is the HPV vaccine is one of the most unnecessary vaccines on the market, it is also the most dangerous! And now they want to unleash it on young boys, and they’re trying to get it approved for older women as well.

Weighing Benefits versus Risks

Even without a potential contamination scare, there are serious risks to every vaccine. The HPV vaccine is a perfect example. So before vaccinating you really need to be certain that the benefits will outweigh those risks.
In the case of Rotarix, along with RotaTeq (a similar vaccine made by Merck), the benefits are very questionable, especially if you live in the United States or another developed country. Typically, when a child in the United States contracts rotavirus, and most do in infancy and early childhood, all that is required is lots of rest, good nutrition and plenty of fluids to prevent dehydration from diarrhea. This infection also provides natural immunity that will protect your child for life.
Along with showing little benefit for a disease that is typically entirely treatable with fluids and rest, a recent drug review by the FDA found that Rotarix is associated with an increase in pneumonia-related deaths in children, compared to a placebo.
So with this particular vaccine, children living in developed countries like the US are potentially taking on serious risks with what appears to be very little benefit — and that was before the contamination was uncovered.
In the case of the HPV vaccine (Gardasil and Cervarix) the choice is clear. It has a high rate of risk and the potential benefits are unproven:
  • In more than 70 percent of cases, HPV clears up on its own within a few weeks or months. In over 90 percent of cases, it’s gone within two years, causing no symptoms or disease.
  • Only about 26 percent of girls and women ages 14 to 59 have been exposed to any HPV strain at all; and
  • Only 2 percent have been exposed to strains 16 or 18 – the two that Gardasil and Cervarix protect against – meaning this vaccine is completely unnecessary because HPV infection very rarely leads to cancer.
  • Women whose partners wore condoms during vaginal intercourse are 70 percent less likely to become infected with HPV. That’s a FAR greater level of protection than you can get from this vaccine!
The moral of the story?
Do your homework before subjecting your children to any vaccine. A great way to get started is to simply use the Search Feature at the top of each of my Web pages and search my site as it contains a litany of research on vaccine safety, and the lack thereof. The National Vaccine Information Center (NVIC) also provides well-referenced information on vaccines and diseases, such as HPV, rotavirus and polio.

Protect Your Right to Informed Consent and Defend Vaccine Exemptions

With all the uncertainty surrounding the safety and efficacy of vaccines, it’s critical to protect your right to make independent health choices and exercise voluntary informed consent to vaccination. It is urgent that everyone in America stand up and fight to protect and expand vaccine informed consent protections in state public health and employment laws. The best way to do this is to get personally involved with your state legislators and educating the leaders in your community.